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Its safety, efficacy, or suitability is not guaranteed outside research settings

BioMed Res Int (2018) 2018:17

To develop cardiac insulin resistance, major factors such as hyperglycemia, hyperlipidemia, oxidative stress, inappropriate activation of sympathetic nervous system and the renin-angiotensin II-aldosterone system (RAAS), and dysregulated secretion of adipokines/cytokines are all significant contributors [139]

Choi KS, Cohn MJ, Harfe BD: Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: implications for disk degeneration and chordoma formation

IL-5 receptor-mediated tyrosine phosphorylation of SH2/SHS-containing proteins and activation of bruton tyrosine and janus-2 kinases

Jia Z, Zhu H, Misra HP, Li Y