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The Nrf2 pathway increases mTOR activity by enhancing its upstream signaling components, particularly through the PI3K/Akt pathway, allowing for coordinated cellular responses to environmental stressors (Gureev et al., 2020

Patients may also experience different side effects depending on if pemetrexed is given alone or combined with other therapies

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It has a great variety of significant physiological functions, such as regulating cell growth and division

10.1016/j.theriogenology.2021.07.014 [DOI] [PubMed] [Google Scholar] Rodrigues V

Recent work has shown that the P187S change causes structural and dynamic changes far from the mutated site via an allosteric mechanism affecting FAD binding at the N-terminal domain and accelerating proteasomal degradation through dynamic effects at the C-terminal domain