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A study using a three-dimensional tumour sphere model combined with CRISPR-Cas9 screening reported that Nrf2 overactivation was essential for lung tumour proliferation and survival, whereas silencing of Nrf2 predisposed spherical cells to ferroptosis, which was also consistent with clinical observations [77]

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To be specific, manganese dioxide nanomaterials, a unique TME response nanomaterial for cancer therapy, have aroused extensive attention for their high biocompatibility, stable structure, as well as easy-to-modify surface

Medicines and Healthcare Products Regulatory Agency, 2005

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Even if studies testing earlier treatment are successful, limited supplies of remdesivir could hinder efforts to make the drug more widely available, at least over the next few months