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10.1186/s12964-015-0112-z Cell Commun
Using a yeast interaction network (The Cell Map 27 ), we identified GSH1 and GSH2 (yeast glutamylcysteine ligase and glutathione synthetase, respectively) as two of the highest scoring synthetic lethal interactions of mtm1, the S.cereviase ortholog for SLC25A39 (p-value=2.78E-28 (GSH1)
In nonstressed cells, low JNK activity is observed due to the sequestration of the protein in a GST : JNK complex (Adler et al
Dasmahapatra, Chayan Dutta, Anitha Myla, Paul B
Origin and physiological roles of inflammation
In others, it makes more sense to build tolerance first by calming reactivity, improving sleep, supporting digestion, or reducing exposures
