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Also underway is a randomized, open-label, phase 3b trial comparing the efficacy of carglumic acid + standard therapy (dietary protein restriction, l-carnitine, metronidazole and vitamin B 12 ) versus standard therapy alone in patients with propionic or methylmalonic aciduria (CAMP

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sexta [124]

Non-hormonal causes should be considered and adequate diagnostic measures taken to rule out malignancy or pregnancy in the event of breakthrough bleeding, as in the case of any abnormal vaginal bleeding

Metabolism of Fat-Soluble Vitamins: Certain apoproteins are involved in the transport and metabolism of fat-soluble vitamins (A, D, E, and K) by transporting them in lipoprotein particles