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Acknowledgments and Funding: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was funded by the Ministry of Science and Technology (MOST 111-2314-B-418-004, MOST 111-2321-B-418-002-, NSTC 112-2321-B-418-004-, and NSTC 112-2314-B-418-010-MY3), Far Eastern Memorial Hospital (FEMH

[DOI] [PubMed] [Google Scholar] 44.Yoshino O, Yamada-Nomoto K, Kano K, et al

Supplementation may help improve mood and reduce symptoms of depression, particularly in those with B12 deficiency

Vitamin B12 contributes to the development of myelin

Rodent work used low mg/kg oral

The risk may be increased with the use of high doses or during prolonged treatments, as well as the use in elderly patients