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FH acts as a tumor suppressor in these cancers, and its reduced expression leads to the accumulation of the transcription factor hypoxia-inducible factor-1 (HIF-1) [1, 17]

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Furthermore, a variety of multiple genetic and environmental factors induce alterations in brain development, leading to ASDs

rhein significantly inhibits TGF-1/Smad2/3 signaling, blocking epithelial-mesenchymal transition in renal tubular epithelial cells while attenuating inflammatory mediator expression through NF-B pathway suppression and enhancing autophagy via AMPK activation to ameliorate hyperglycemia-induced glomerulosclerosis

doi: 10.3390/ijms20184497 82

Skin Regeneration Stimulates keratinocyte proliferation and fibroblast activity - widely cited in cosmetic and dermatology research for skin repair applications