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However, and this is important, 37.5% of children with preexisting sleep problems no longer had those sleep problems at the highest methylphenidate dose

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Limitations were the small number of studies included in the statistical analysis, the inclusion of observational studies, the potential bias from selecting only English-language studies, the lack of very long-term follow-up data, the limited geographical origin of population and finally the lack of stratification by fibrosis

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