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Author contributions LC performed the experiments, contributed to experimental design, analyzed data and wrote the manuscript

Stage III

A cooling gel is placed on the area to be treated, and then the treatment begins

The metabolic adaptations that occur are limited to the enhanced expression of beta-3 adrenergic receptors in adipose tissue, which actually represents a favorable metabolic improvement rather than a dependence-creating change

Essential for patients who want to maximize the fat-burning effect of their weight loss program
