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However, anecdotal reports from online forums cited in a 2025 systematic review included anxiety and panic attacks, depression and anhedonia, insomnia, heart palpitations, fatigue and weakness, and loss of appetite

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Since M2-like macrophages outnumber M1-like macrophages within the TME, the therapeutic approaches aimed at macrophage reprogramming are of particular interest

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[DOI] [PMC free article] [PubMed] [Google Scholar] Sutherland MW, Glass M, et al

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