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The usual dose is 1000 mcg

An open-label RCT compared two dosing regimens, i.m

In the context of brain ischemic injury in vivo , HGF inhibits apoptosis via transient activation of ERK (Niimura et al., 2006a)

Use different areas of the abdomen, thighs, or upper arms for each injection

At that concentration, a 300 mcg dose is about 0.18 mL (18 units on a U-100 syringe) and a 500 mcg dose is about 0.30 mL (30 units)

Oral administration faces hepatic first-pass metabolism, reducing bioavailability to approximately 4050% of subcutaneous routes, but offers convenience for longer-term studies where daily injections create compliance challenges