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NanuaSZickSMAndradeJESajjanUSBurgessJRLukacsNWet al

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In many cell types, pyruvate carboxylation to oxaloacetate is suppressed, thereby rendering them reliant on glutamine catabolism to replenish the oxaloacetate that can condense with acetylCoA to produce citrate and drive the TCA cycle (DeBerardinis et al , 2007)

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Overexpression of liver-derived Gpld1 can improve hippocampal neurogenesis and cognitive performance in aged rodents [32], suggesting that Gpld1 has the potential to restore neuronal plasticity and function in brain disorders