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This suggested that SF was exerting a pharmacodynamic action that reflected induction of GSTs by SF, thereby shunting the reactive epoxide intermediate away from nucleophiles in DNA, where it would have mutagenic and carcinogenic effects, and toward GSH, which allowed it to be further metabolized and excreted in the urine

[DOI] [PMC free article] [PubMed] [Google Scholar] Zaganas, I

doi: 10.1371/JOURNAL.PONE.0177623 17 BurmeisterS

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Discussion In recent years, interest on the research of herb medicine has increased all over the world

By contrast, after pretreatment with saline placebo, GSH produced cough in three patients and mild breathlessness in one, inducing a sig- nificant increase in Rrs (change from placebo, 10.89 6 0.78 cm H 2 O