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Conversely, SIRT3 overexpression has the opposite effects, 105 suggesting that SIRT3 inhibits AKT-dependent mitochondrial metabolism and EMT, thereby promoting ferroptosis

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Pluripotent Stem Cells Recent advancements in genetics and regenerative medicine have spurred the quest for innovative therapies aimed at halting or slowing the advancement of specific neurodegenerative disorders through the utilization of pluripotent stem cells, which represent a promising alternative for cellular therapy in localized neurodegeneration, such as PD [85]

These examples illustrate that carotenoids can both protect normal cells and selectively kill cancer cells by shifting redox and signaling balances toward cell cycle arrest and apoptosis

Studies have shown that vitamin C treatment reduces leukocyte recruitment in mice with pulmonary fibrosis by paraquat (126), which may indicate a direct relationship between vitamin C and immune cells