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It is produced in the liver and nerve cells in an intracellular concentration of nearly 1-10mmol/L

The activation of SODs by a FOXO transcription factor (FOXO4) appears to contradict their antioxidant effect

doi: 10.1038/s41590-021-00913-5 171 HuangY.MahleyR

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In view of what was observed in this study, we hypothesised that VACV promotes a reduction in the redox environment to initiate host shutdown to escape the hosts antiviral immune response
