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Pairing (2000) SOX off: with partners in the regulation of embryonic development

Without formal reproductive toxicity studies following OECD Test Guideline 414 (prenatal developmental toxicity) and 416 (two-generation reproduction toxicity), we are operating without the data that regulatory science requires before concluding a compound is safe for use during conception attempts or pregnancy

Barthel, A., Schmoll, D

[3] described three dominant hypotheses of HH, which are as follows: (1) increased intra-abdominal pressure that moves the gastroesophageal junction into the thorax cavity, (2) esophageal shortening from innate causes or acquired caused by fibrosis, and (3) widening of the orifice from innate or acquired changes in the crural muscles or connective tissue of the diaphragm

In-line clarification is the removal of suspended solids through the addition of in-line coagulant followed by rapid filtration

Docetaxel cleaves GSDME via the ROS/JNK/caspase-3 pathway, and its pyroptotic effect can be enhanced by demethylation of the DFNA5 gene, highlighting the role of epigenetic regulation in chemosensitisation [70]