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In addition to downregulating FASN at the posttranslational level, GSH depletion also decreased the key lipogenic genes at the transcriptional level, most notably Scd1 and Srebf1 (Figure 3, AC)

Rezvanfar MA (2005) Chemical-specific adjustment factors for Interspecies differences and human variability: guidance document for use of data in dose/concentrationresponse assessment, 3rd edn

[DOI] [PMC free article] [PubMed] [Google Scholar] 196.Buckley J.P., Kim H., Wong E., Rebholz C.M

Antioxidant treatment to reduce mortality and serious adverse events in adult surgical patients: a systematic review with meta-analysis and trial sequential analysis

All the other solvents and reagents were used as received without further purification

Glutathione compartmentalization and its role in glutathionylation and other regulatory processes of cellular pathways