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Curcumin formulations with enhanced bioavailability are thought to achieve therapeutic concentrations in plasma, which can reach dermal tissues to exert antiaging effects, particularly relevant for women experiencing estrogen decline [64]
The redox state significantly influences the gut microbiota's composition and activity, affecting microbial metabolism and their interactions with the host
The TGF-1/Smad3 pathway is a key driver of this process, inducing the expression of fibrotic markers such as -SMA and collagen I, promoting interstitial remodeling
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These results suggest that CYP2E1 plays an important role in ethanol-induced fatty liver disease and oxidative stress
[DOI] [Google Scholar] 11.Metges C.C
