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Important safety considerations include: Inform your GP about all supplements you are taking Avoid self-treating suspected deficiency without medical assessment, as supplementation can mask underlying pernicious anaemia whilst allowing neurological damage to progress Do not start high-dose folic acid supplements before B12 deficiency is excluded, as this can worsen neurological damage Check for interactions if taking medications such as metformin, chloramphenicol, or proton pump inhibitors Monitor response through appropriate blood tests if treating deficiency Pregnant women, individuals with Leber's disease (a rare hereditary eye condition), and those with cobalt allergy should consult healthcare professionals before supplementing

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Functional vitamin B12 deficiency is when an individuals B12 level may appear normal but there is a problem with the proteins that help transport the vitamin B12

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Our primary objective is to enhance our understanding of this condition and to develop potential innovative approaches to improve the lives of individuals affected by plaque psoriasis