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Cancer Cell 17 , 98110 (2010)

The pain usually affects the lower extremities first and extends upward through hosiery-like sensory abnormalities [81, 82]

10.1091/mbc.12.5.1445 18 BremH.StojadinovicO.DiegelmannR

Patients with significant symptoms that do not improve concurrently with the physical symptomatology need clinical and psychological support both at home and at work

Currently, cancer treatment faces three main challenges: limitations of traditional drug development models, inherent flaws of single-target drugs, and the complexity of tumor mechanisms

Organ-specific toxicity is another critical area of concern
