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This special interplay further highlights that the loss of any one system can overwhelm the compensatory capacity of the others, forcing the CNS into a state of redox imbalance, glial activation, and progressive inflammation (Figure 1)

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10.1016/j.freeradbiomed.2004.06.011 [DOI] [PubMed] [Google Scholar] Estrela J.M., Ortega A., and Obrador E