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Mechanistically, alterations in gut microbial metabolites such as SCFAs could affect the integrity of the BBB, induce systemic endotoxemia, and activate microglia so as to impact disease progression

Immune Response Gene-1 [IRG1]/itaconate protect against multi-organ injury via inhibiting gasdermin D-mediated pyroptosis and inflammatory response

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D.SoldatovicI.ColakE.Sumarac-DumanovicM.JaneskiH.et al (2017)

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Other exercise mimetics have been tested, but none have made it to market, in part because it takes years to develop a new drug