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Heavier individuals may require higher doses to achieve equivalent NNMT inhibition due to larger adipose tissue mass and potentially higher baseline NNMT activity

Schwarcz R, Pellicciari R (2002)

Mechanistically, we identified a defining characteristic of tumors harboring moderate mtDNA mutations: the early and sustained activation of ribosomal pathways, which we designate as a ribosomal storm and propose as a compensatory adaptive response

J Alzheimers Dis 16:763

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However, the cellular sources of these cytokines are partially unknown