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The same study also observed the impact of riboflavin levels on blood pressure, to assess whether this interacted with MTHFR genotype

Klein A, Schiffner R, Schiffner-Rohe J, Einsele-Kramer B, Heinlin J, Stolz W, Landthaler M

Refractory anxiety may cause glutamate receptor damage in the hippocampus and neuronal atrophy in the prefrontal cortex (PFC), which can result in mood disturbances and cognitive deficits [205]

Anxiety, Depression, and the Microbiome: A Role for Gut Peptides

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This suggests that these metabolites reflect metabolic integrity of cells (see SA8 for further discussion)
