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It has been confirmed as a novel metabolite of Hcy, which is generated by the conversion of Hcy to Hcy-thiolactone catalyzed by methionyl-tRNA synthetase 15

B.MacdonaldC

171 YamazakiM.ShibataM.NishiyamaY.SpringobK.KitayamaM.ShimadaN.et al (2008)

Cao F, Gui SY, Gao X, Zhang W, Fu ZY, Tao LM, Jiang ZX, Chen X, Qian H, Wang X

It was recently estimated that the A4V mutation occurred 540 generations (~12,000 years) ago

Environ Health Perspect (2002) 110 Suppl 5:8016
