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Advanced materials (Deerfield Beach, Fla.) 37(4):e2405847 Wang C, Yuan F, Yan Z, Zhang T, Fu C, Li Y, Dai G, Kim HS, Xia S, Yu L, Debnath S, Ren WX, Shu J, Qiu M, Kim JS (2025) High entropy 2d layered double hydroxide nanosheet toward cascaded nanozyme-initiated chemodynamic and immune synergistic therapy

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These excipients play distinct and complementary roles in overcoming anatomical and physiological barriers, ultimately enhancing the therapeutic performance of intranasal formulations (Gnger and Schindowski, 2018)

This may be because copper serves as a cofactor for cytochrome c oxidase in the mitochondria (8), which is involved in electron transport and ATP synthesis in the mitochondrial respiratory chain