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ACKNOWLEDGEMENTS We thank Lorenza Lanini and Ray Hill, independent medical writers acting on behalf of Springer Healthcare Italy, who provided medical writing support, and Tracy Harrison, of Springer Healthcare Communications, who provided editorial assistance post submission

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While these diseases have distinct etiologies and pathologies, they all involve neuronal loss and sustained activation of the brains immune system, including microglia and astrocytes ( A key driver of neuronal injury is oxidative stress, which arises when the generation of reactive oxygen species (ROS) overwhelms the brains antioxidant defenses, one such defense being glutathione (GSH) (Tfilin et al., 2023)

Does glutathione support the body's natural detoxification processes

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