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Beaino, W

A novel superfamily of bridge-like lipid transfer proteins

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Broadly speaking, there are two large compartmentsthe avascular epidermis and the vascular dermiswith many cell types distributed in a connective tissue matrix, largely created by fibroblasts.[1] The outer layer or epidermis is made primarily of keratinocytes but has several other minor cell populations

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for example, -hydroxyceramides and -glucosylceramides are attached to surface proteins of skin, and inositol-phosphoceramides are used as membrane anchors for some fungal proteins in a manner analogous to the glycosylphosphatidylinositol anchors that are attached to proteins in other eukaryotes