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[DOI] [PubMed] [Google Scholar] 148.Gao Q, Zhu H, Dong L et al

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26 , 648659.e8 (2017)

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This limited efficacy is likely due to several critical challenges, including the tumors molecular heterogeneity, the dynamic evolution of its genetic profile, and the restrictive nature of the blood-brain barrier that impedes effective drug delivery

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Moreover, most of the glutathionylated proteins studied are cytosolic and not much is known about what happens in other cellular compartments

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In addition to genetic regulators, intracellular iron accumulation, excessive lipid peroxidation, and small molecules can also trigger ferroptosis [6, 17]

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Blood 88 , 31953199 (1996)

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