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10.1371/journal.pone.0171344 46 HancockL
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Mutations in parkin ( PRKN ) or phosphate and tensin homolog-induced kinase 1 ( PINK1 ) prevent cells from responding to mitochondrial damage by altering the balance of fusion to fission and disrupting mitophagy, which leads to familial forms of PD [97, 98]

2, MTHFR catalyzes the physiologically irreversible reduction of 5,10-methylene THF to 5-methyltetrahydrofolate (5-methyl THF), and plays a critical role in one-carbon metabolism for the reaction of producing methyl groups to participate in epigenetic regulation 18

In a systematic review and meta-analysis comprising 25 randomized controlled trials (RCTs) (12 among participants with diabetes and 6 among those at high risk of T2D), we found that magnesium supplementation reduced fasting plasma glucose in people with T2D vs

For individuals with insulin resistance and DM, the viewpoint of Corona et al indicates that metformin, glucagon-like peptide-1 agonist, and sodium-glucose cotransporter-2 inhibitor are more effective in improving ED [167]
