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X., et al., Icaritin and Intratumoral Injection of CpG Treatment Synergistically Promote T Cell Infiltration and Antitumor Immune Response in Mice, International Immunopharmacology 111 (2022): 12

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Analysis of the movements of the lamina cribrosa in glaucoma shows that the greatest mechanical damage is exerted on axons located in the peripheral part of the ON, which correlates with clinical findings showing that vision loss begins in the peripheral zone of the visual field ( Although these physical changes in the lamina cribrosa may not be the cause of axonal loss in the early stages of glaucoma, stress and strain due to elevated IOP may accumulate, contributing to axonal damage and loss ( The effect of this translaminar pressure gradient on axons leads to ischemia/hypoxia damage, blockade of axonal transport and deprivation of neurotrophic factors, ultimately resulting in apoptosis of RGCs (Nickells, 2007