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These compounds yielded significant improvements in potency, selectivity, and pharmacokinetic properties while maintaining key interactions with JNK3

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When cells lack the nutrition they need, they can't keep up with the metabolic demands of the body

In addition to serine phosphorylation of the insulin receptor, various PKC isoforms have been shown to phosphorylate IRS1 and IRS2 further impairing the ability of these insulin receptor substrates to associate with the insulin receptor and downstream effector proteins such as PI3K

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