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Key References NAD+ declines with age and influences cellular aging pathways: Verdin E

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Similarly, the P16INK4a gene, part of the CDKN2a/INK4a/ARF locus, generates two protein products, one of which regulates P53 stability, while the other, the P16INK4a protein, inhibits CDK4/6 [202]

[DOI] [PubMed] [Google Scholar] 44.Knauf F, Ko N, Jiang Z, et al

Materials and methods Clinical samples of hepatocellular carcinoma patients Human hepatocellular carcinoma (HCC) cancer tumor tissues and matched adjacent tissues ( n = 20) were collected from Cancer Hospital Affiliated to Harbin Medical University for qRT- PCR, western blot and Eliza assays

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