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ROS, stimulated by NOX, activates the canonical WNT/-catenin pathway through the oxidization and inactivation of the nucleoredoxin (a redox-sensitive regulator), thus stimulating the cancer process [53]

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These interactions can trigger a series of immunoregulatory responses, involving both innate and adaptive immune systems and including cross-presentation of antigens, activation of CD 8 + T cells and CD 4 + T cells, phagocytosis, complement-mediated antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC)

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Lancet (2005) 366:21127.10.1016/S0140-6736(05)67889-0 4 ClarkCM

Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association