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[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Galarraga M, Campion J, Munoz-Barrutia A, Boque N, Moreno H, Martinez JA, Milagro F, Ortiz-de-Solorzano C
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Longevity pathway activation NAD+ plays a crucial role in activating sirtuins, a family of proteins involved in cellular repair, stress response, and aging

The result is a vicious cycle where declining NAD+ leads to worse metabolic function, which can lead to weight gain, which increases NNMT activity further
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