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Disease course varies, with some patients experiencing spontaneous remission and others developing chronicity (Fig

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Another finding from the NIH highlights that Metformin users showed significantly lower B12 levels over time compared to non-users , making regular monitoring important for diabetic patients on long term medication

The free radical theory of aging postulates that accumulated damage from reactive oxygen species (ROS) over time contributes heavily to the functional decline of cells and tissues

For instance, Atlas and colleagues showed that HIV+ patients and those with psychotic symptoms had higher KYNA levels in the CSF compared to non-psychotic patients [107]
Liu X, Wang M, Jiang Y, Zhang X, Shi C, Zeng F, et al
