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In contrast to other lipases, PNPLA3 is upregulated by increased insulin levels and the lipogenic transcription factor SREBP1c 96

doi:10.1371/journal.pbio.0060202

Genetic mutations associated with non-response include homozygous mutations for human leukocyte antigen (HLA) DRB1*0301, HLA-B8, SC01, DR-3, HLAB44, FC-31, and DR-7

However, the process of partial hydrogenation of oils, which is used to make them harder in manufacturing margarine and similar products, can also isomerize the double bonds, generating large amounts of trans fats

J Assist Reprod Genet