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Description
This sensor reports on the GSH redox potential ( E GSH ) established by the ratio GSH:GSSG through a redox relay involving cysteines in cellular glutaredoxins, as an indirect measurement of ROS 27

10.1016/j.brs.2021.10.268 Brain Stimul
Kwong, M., Y.W

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Additionally, frataxin deficiency in dorsal root ganglia disrupts iron homeostasis and impairs Nrf2 activation and its downstream redox signaling pathways, thereby promoting ferroptotic injury (391)

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