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Notwithstanding, some clinically relevant complex I inhibitors such as metformin, MS-L6 and IACS-010759 have shown low toxicity in vitro in mouse liver organoids, rat hepatocytes, non tumoral human cells (lymphocytes, skin fibroblast, lung fibroblast) and murine embryonic fibroblasts in comparison with rotenone (5961), and their administration inhibits tumor growth in murine xenograft models (human colon cancer, human non-Hodgkins B-cell lymphoma cancer, acute myeloid leukemia, glioblastoma and neuroblastoma) without toxicity (56, 59, 61)

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