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Overview The peptide appears to exert potential actions via binding with intracellular molecules and cell membrane receptors, possibly inducing cytoprotective and/or neuroprotective functions

To adopt the scientific lingo, we say that Vitamin B2 is a co-factor for the MTHFR enzyme

NAM transporters have also been investigated and recently identified as SLC29A1 and SLC29A2, which are also able to transport NR 73

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This means, the presence of both mutated COMT and mutated MTHFR genes, together, may worsen the problem