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NAPQI can then interact with cellular macromolecules, resulting in toxicity, or it can be detoxified by undergoing GSH conjugation

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NLRP3, upon recognition, activates downstream signals, and mtDNA can induce the assembly of its inflammasome through potassium efflux

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Despite its exclusive synthesis in the cytosol, GSH is compartmentalized in different organelles, predominantly in nuclei, endoplasmic reticulum (ER), and mitochondria