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identified PERK as a specific receptor for TMAO, demonstrating that TMAO directly activates the PERK branch of the UPR at physiological concentrations, thereby inducing the transcription factor FoxO1, which is implicated in metabolic and inflammatory diseases (81)

(36) found no significant liver enzyme improvement in pediatric patients, primarily based on a single pediatric study that itself showed no clear benefit (68)

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A 4-week, parallel, double-blind, randomized controlled trial (N = 27 LOE2b) was conducted on elderly patients with HE receiving 6 g of LC daily versus equivalent placebo for 4 weeks

For example, the muco-aqueous tear layer greatly reduces drug residence time [40]

Hershman, D