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It also activates pathways like Egr-1, NAB2, and JAK-2

Fan S, Zheng Y, Liu X, Fang W, Chen X, Liao W et al (2018) Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimers disease

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31,32 A moderate expression of D1 receptors has been reported in the entopeduncular nucleus, cerebral aqueduct, and ventricles, 33 with a lower density in the dorsolateral prefrontal cortex, cingulate cortex, and hippocampus

According to the landmark paper The Hallmarks of Aging, mitochondrial dysfunction is considered one of the central biological processes involved in aging itself