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To reduce error, pretreatment values were the mean of measurements on days 2, 1 and 0, and final values were the mean of days 18, 19 and 20

In addition, expression of the necroptosis markers phospho RIPK3 and phospho MLKL were decreased in Beas-2B cells transfected with GSR siRNA compared with control siRNA after treatment with the necroptosis inducers TNF, smac mimetic, and Z-VAD (Figure 6E)

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In addition, extensive study of neoplastic tissues by 5UTR CG-methylated islands analysis show the inactivation of the GSTP1, due to the hypermethylation