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Untreated vitamin B12 deficiency can gradually damage the nervous system and reduce healthy red blood cell production

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Overexpression of parkin, an E3 ubiquitin ligase, can promote mitophagy and protect RGCs in glaucoma (Dai et al., 2018)
Niu L-Y, Guan Y-S, Chen Y-Z, Wu L-Z, Tung C-H, Yang Q-Z
doi: 10.1038/s41585-020-0332-x 2 StamatelouKGoldfarbDS
Koob and Volkow, 2010)
