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doi: 10.1083/jcb.200910104

Opioid use affects antioxidant activity and purine metabolism

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One possible reason is that the NH 4 + cation might compete with the transport of other ions across neural membranes, altering transmembrane potentials and, hence, neural function

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Although some interesting features are noted in this system, the Yap1-cCRD variant must be expressed in host cells and, since it is protein-based, it may exhibit substrate bias when compared to chemical-based probes