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This prospective, phase IV study used an integrated genomic analysis to identify markers associated with 1-month change in IGF-I (IGF-I) following initiation of recombinant human (r-h)GH therapy in treatment-nave children with GH deficiency (GHD) (n=166) or Turner syndrome (TS) (n=147)

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The treatment significantly ameliorated core ASD-like behaviors, including improved sociability (increased stranger interaction time, P<0.0001), reduced repetitive behaviors (decreased marble-burying, P<0.0001