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Oxidative stress leads to neuronal inflammation and is part of the therapeutic goal in all neuroprotective treatments because it causes apoptosis (2, 3, 8, 9)

Jujuboside A ameliorates high fat diet and streptozotocin induced diabetic nephropathy via suppressing oxidative stress, apoptosis, and enhancing autophagy

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96,97 Mechanistically, the beneficial role of eosinophils under these contexts requires crosstalk and coordination with complex cellular networks encompassing other immune cells and stromal cells in a manner that blurs the lines between canonical type I and type II immune responses

One unique feature of the HGA/MVA pathway is that shikimate (via tyrosine) ultimately provides the quinone moiety of the 1,4-naphthalenoid ring, compared with the OSB and 4HBA/MVA pathways in which shikimate (via isochorismate and phenylalanine, respectively) provides the benzene moiety (Figure 2)
