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Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trialJAMA, 311 (2014), pp

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The possible mechanisms of TUDCA in suppressing apoptosis might involve in the activation of autophagy by increasing expression of autophagic related proteins (Beclin-1,LC3II/I) or inhibition of the ER stress via decreasing ER stress-related factors (IRE1, Chop, ATF6, Grp78 and Erdj4 ) [165,166,167,168]

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26 However, they did not observe any indications of c-Myc transcriptionally regulating GLS1 despite the presence of a typical E-box sequence in its first intron

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