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4-(pyridin-2-yldiazenyl)phenol (200 mg, 1 mmol) was dissolved in a mixture of DMF (10 mL), potassium carbonate (207 mg, 1.5 mmol), and potassium iodide(183 mg, 1.1 mmol)
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One of the most important concerns is that AX can be readily converted to astacene (3,3-dihydroxy-2,3,2,3-tetradehydro-,-carotene-4,4-dione) through oxidation in alkaline solutions in the presence of oxygen (Supplementary Figure S1) [67]

Characterization of bacterial -carotene 3,3-hydroxylases, CrtZ, and P450 in astaxanthin biosynthetic pathway and adonirubin production by gene combination in Escherichia coli
Heterologous production of fungal secondary metabolites in aspergilli

Calada D, Vianello D, Giampieri E, Sala C, Castellani G, de Graaf A et al (2014) The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach

Prurigo pigmentosa following ketogenic diet and bariatric surgery: a growing association